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Steinbeck emphasizes dreams throughout the book. George aspires to independence, to be his own boss, to have a homestead, and most importantly to be "somebody". Lennie aspires to be with George on his independent homestead, and to quench his fixation on soft objects. Candy aspires to reassert his responsibility lost with the death of his dog, and for security for his old age — on George's homestead. Crooks aspires to a small homestead where he can express self-respect, acceptance, and security. Curley's wife dreams to be an actress, to satisfy her desire for fame lost when she married Curley.
Loneliness is a significant factor in several characters' lives. Candy is lonely after his dog is gone. Curley's wife is lonely because her husband is not the friend she hoped for —- she deals with her loneliness by flirting with the men on the ranch, which causes Curley to increase his abusiveness and jealousy. The companionship of George and Lennie is the result of loneliness. Crooks states the theme candidly as "A guy goes nuts if he ain't got nobody. Don't make no difference who the guy is, long's he's with you." The author further reinforces this theme through subtle methods by situating the story near the town of Soledad, which means "solitude" in Spanish.
Despite the need for companionship, Steinbeck emphasizes how the nature of loneliness is sustained though the barriers established from acting inhuman to one another. The loneliness of Curley's wife is upheld by Curley's...